Comparative Pain Control Between 0.2 or 0.3 Spinal Morphine and 0.25 or 0.5 % Bupivacaine for FNB After TKA

Mahidol University160 enrolled

Overview

Comparative efficacy of 24 and 48 hours post operative pain control in single total knee replacement between intrathecal bupivacaine with 0.2 or 0.3 mg morphine together with 0.25 or 0.5 % bupivacaine for single femoral nerve block

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

160

Conditions

Post Operative Pain Total Knee Replacement

Interventions

morphine and bupivacaineDRUG

0.3 mg morphine for spinal together with 0.5% bupivacaine for femoral nerve block

spinal morphine and marcaineDRUG

0.3 mg spinal morphine together with 0.25% bupivacaine for femoral nerve block

morphine and bupivacaineDRUG

0.2 mg morphine for spinal 0.5% bupivacaine for femoral nerve block

Eligibility

Sex: ALLMin age: 45 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Single elective total knee replacement in ASA 1-3 without significant cardiovascular limitation Exclusion Criteria: * patient at risk in usage COX-2 for post operative pain control

Locations (1)

Siriraj Hospital

Bangkok, Bangkoknoi, Thailand

Outcomes

Primary Outcomes

Global assessment in post operative pain control

Time frame: Begining of first enrollment in december 2008

Secondary Outcomes

Global assessment of post operative pain in 48 HOURS AND SIDE EFFECTS

Time frame: first enrollment in December 2008

Data from ClinicalTrials.gov

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