Effects of Chronic Smoking on Circulating Endothelial and Platelet-derived Microparticle

Early Phase 1CompletedNCT00795249

Kurume University100 enrolled

Overview

The investigators hypothesized that circulating EMP is a useful surrogate marker of early stage of endothelial damage. To determine the effects of chronic smoking on circulating EMP, from healthy volunteers who have habit of chronic smoking, peripheral blood is drawn at the time of flow-mediated dilatation (FMD) examination. Spot urine is also collected. Circulating EMPs are counted using flow-cytometry. After 2-week smoking cessation, the measurements were repeated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

100

Conditions

Atherosclerosis

Interventions

smoking cessationBEHAVIORAL

After baseline examination, the group is asked to quit smoking for 2 weeks.

Eligibility

Sex: MALEMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy individuals who have no coronary risk factors Exclusion Criteria: * hypertension * dyslipidemia * chronic kidney disease * liver dysfunction * obesity (BMI\>25.0) * cerebrovascular disease * other severe systemic diseases (cancer, inflammatory diseases, etc)

Locations (1)

Kurume University Hospital

Kurume, Fukuoka, Japan

Outcomes

Primary Outcomes

The number of circulating EMP

Time frame: 2 weeks

Secondary Outcomes

FMD

Time frame: 2 weeks

Data from ClinicalTrials.gov

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