Uterine curettage is usually performed under the anesthesia of propofol-fentanyl or para-cervical block,of which generally has significant incidence of respiratory depression which increases the demand on intraoperative monitoring, or has unavoidable insufficient blockade which results in intraoperative suffering of pain. Butorphanol is an analgesic with combined effects on mu and kappa opioid receptors leading to a role as analgesia and sedation. The investigators hypothesized that combined propofol with butorphanol during uterine curettage would produce optimal effectiveness of these two drugs by adding sedative and analgesic effects together. In addition, it would decrease the intraoperative consumption of propofol without increase the incidence of side effects. Furthermore, such combination would alleviate postoperative pain.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
150
Combined anesthesia with propofol (2-2.5mg/kg) and fentanyl (5 μg)
Combined anesthesia with propofol (2-2.5 mg/kg) and butorphanol (1mg)
Nanjing Maternal and Child Health Care Hospital
Nanjing, Jiangsu, China
Intraoperative awareness
Time frame: During the whole process of anesthesia
Bispectral Index (BIS) value
Time frame: During the whole process of anesthesia
Anesthetic consumptions
Time frame: From the start of operation to the end of surgical procedures
Postoperative pain
Time frame: Since the end of the operation to 48 h follow-up.
Postoperative bleeding
Time frame: Since the end of operation to 48 h follow-up
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