This study will evaluate the safety and tolerability of repeated subcutaneous injections of CAD106 in patients with mid Alzheimer's disease
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
31
ATP Clinical Research
Costa Mesa, California, United States
Alpine Clinical Research Center
Boulder, Colorado, United States
Sunrise Clinical Research
Hollywood, Florida, United States
Safety/tolerability of repeated injection of CAD106 at multiple timepoints including but not limited to screening, baseline and through the end of the study (adverse events, physical/neurologic exams, vital signs, 12- lead ECGs, clinical labs, brain MRI)
Time frame: 52 weeks
Immune response at multiple timepoints including but not limited to screening, baseline and through the end of the study.
Time frame: 52 weeks
Cognitive assessments at multiple timepoints including but not limited to screening, baseline and through the end of the study.
Time frame: 52 weeks
Functional assessments at multiple timepoints including but not limited to screening, baseline and through the end of the study.
Time frame: 52 weeks
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Alexian Brothers Neuroscience Institute
Elk Grove Village, Illinois, United States
Indiana University School of Medicine
Indianapolis, Indiana, United States
MidAmerica NeuroScience Research Foundation
Lenexa, Kansas, United States
Columbia University Medical Center
New York, New York, United States
Drexel University College of Medicine
Philadelphia, Pennsylvania, United States
NOCCR Knoxville
Knoxville, Tennessee, United States
University of Texas Southwestern
Dallas, Texas, United States