Implantation of the human embryo is the limiting factor in the success of invitro-fertilization and embryo transfer(IVF-ET).We wanted to find out whether creating a local injury to the endometrium in the non-transfer cycle would improve the IVF-ET outcome in the subsequent cycle.We believe that the injury created causes release of substances which help in implantation.
Study Design and Subjects: This is a randomized control study designed to evaluate the effect of local injury to the endometrium in non-transfer cycle in patients with previous failed IVF. Patients will be randomly allotted to control and intervention group The patients in the intervention group Pipelle endometrial sampling 7-10th day and 24-26th day in the cycle prior to IVF transfer cycle. Outcome Measures: Clinical pregnancy rate,implantation rate and ongoing pregnancy rate. SAMPLE SIZE: 100 PATIENTS (50 in each group).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
99
Pipelle endometrial sampling will be done twice between 7th to 10th day and 24th to 26th d in the cycle prior to IVF.
Bangalore Assisted Conception Centre
Bangalore, Karnataka, India
PRIMARY OUTCOME MEASURE:IMPLANTATION RATE;
Time frame: 9 MONTHS
CLINICAL PREGNANCY RATE,ONGOING PREGNANCY RATE
Time frame: 9 MONTHS
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