Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect. We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.
Double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
18
Ketamine bolus preoperative and syringe pump peroperative, and morphine postoperative (PCA)
Bolus preoperative of NaCl and syringe pump peroperative of NaCl, and morphine postoperative (PCA)
Bolus preoperative of NaCl and syringe pump peroperative of Ketamine, and morphine postoperative (PCA)
Service d'anesthesie-reanimation - Hôpital Bicêtre
Le Kremlin-Bicêtre, France
Morphine consumption in PACU and in hospitalisation room
Time frame: at 24 and 48 hours
Postoperative Visual Analogic Score of pain
Time frame: in Recovery Room, at 24 and 48 hours, in the ward
Postoperative Measure of mechanical hyperalgesia by Von Frey filament device
Time frame: 24 and 48 hours in the ward
Postoperative measure Ketamine and Nor-Ketamine blood levels
Time frame: at 24 and 48 hours in the ward
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