Study to Evaluate Nosocomial Transmission of Influenza

University Hospitals, Leicester50 enrolled

Overview

The purpose of this study is to investigate whether influenza can be reliably transmitted from children to susceptible contacts in a health care setting. The goal is to develop a transmission that can then be used to assess interventions to prevent transmission Research objectives: To develop a model to investigate the frequency of influenza transmission from an infected child to a susceptible health care worker Research Hypotheses: Influenza viruses can be transmitted from infected children to exposed health care workers

CHildren with influenza infection presenting to ED will be identified by RAT. Healthy healthcare worker subjects will expose themselves and perform specific activities with the child. subjects will be followed by diary card, clinical symptom scores and virology swabs to assess frequency of transmission

Study Type

OBSERVATIONAL

Enrollment

Conditions

Influenza

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * Infected Children * Age \< 16 years * Parents or legal guardians willing to give informed written consent * Presenting with a febrile illness confirmed as influenza by near patient rapid antigen testing * Healthy volunteers * Willing to give informed written consent Exclusion criteria * Children * No parents or legal guardians able to give informed consent * Healthy volunteers * known allergy to oseltamivir or zanamivir * presence of underlying condition or concomitant therapy requiring dose alteration of oseltamivir (severe renal or hepatic failure; methotrexate and probenecid) * underlying immunosuppressive disorder * known galactose intolerance * underlying chronic medical condition known to increase risk of influenza-related complications (including asthma, chronic pulmonary airways disease, chronic cardiovascular disease, diabetes mellitus, chronic neurological disorder) * inability or contraindication to collection of nasal swabs * previous influenza vaccination within 2 years * current smoker * pregnancy

Locations (1)

University Hospitals Leicester

Leicester, Leics, United Kingdom

Outcomes

Primary Outcomes

Frequency of transmission of influenza

Time frame: 1 weeks

Central Contacts

Iain Stephenson, FRCP

CONTACT

+44 116 258 6952 iain.stephenson@uhl-tr.nhs.uk

Data from ClinicalTrials.gov

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