This trial uses a type of radiotherapy called intensity modulated radiotherapy (IMRT), which is able to deliver the radiation to the prostate while delivering less dose to the surrounding normal organs compared with standard 3D conformal radiotherapy presently used at the BCCA. This trial will use RapidArc IMRT, which is a new way of delivering IMRT, where the radiation dose is delivered in a single rotation of the radiotherapy machine around the patient. This new method of delivering IMRT has been shown to be at least as good as conventional IMRT at delivering the dose, and takes less time to do so. The aim of this study is to deliver a higher radiation dose to the prostate gland than the standard treatment while not increasing dose to the normal organs. In this way, it is hoped that the likelihood of the cancer coming back will be reduced without causing an increase in side-effects.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
10
Each patient will undergo a course of intensity modulated external beam radiation therapy (IMRT) using RapidArc for optimization and delivery. Doses of radiotherapy are as follows: * The prescription dose will be 73.7 Gy in 28 fractions * A simultaneous intraprostatic boost will be given to as much of the CTV as possible without contravening OAR dose constraints.
British Columbia Cancer Agency - Vancouver Centre
Vancouver, British Columbia, Canada
Incidence of grade 2-4 gastrointestinal and genitourinary toxicity
Time frame: No time frame (post-treatment)
Quality of life (EPIC, IPSS and SHIM questionnaires)
Time frame: Post-treatment; every 6 mos until 5 years - then annual
Percentage of CTV treated to boost dose
Time frame: Immediately post-treatment
Time-cost analysis compared to external-beam radiotherapy with brachytherapy boost
Time frame: No time frame
Accuracy of surrogate urethra compared to T2-MRI localization
Time frame: No time frame
Quantification of dose received by lesions identified by diffusion-weighted and dynamic contrast enhanced MRI
Time frame: No time frame
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