Prediction of Post-Cesarean Section Pain

University of Washington800 enrolled

Overview

The purpose of this study is to determine if dynamic psychophysical testing along with genetic screening will allow to identify pre-operatively women who will suffer severe acute pain post-operatively and the subset who may experience chronic pain following cesarean section.

Study Type

OBSERVATIONAL

Enrollment

800

Conditions

Postoperative Pain

Interventions

Psychophysical testing, questionnaires, and geneticsOTHER

pre-operative psychophysical testing of endogenous pain modulation, pre-operative questionnaires, peri- and post-operative data collection, long term follow-up assessing chronic pain, SNP association analysis, and whole genome scanning association studies

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Women age 18-50 scheduled for an elective cesarean section (1st or 2nd cesarean section) Exclusion Criteria: Women who: * have taken opioids, acetaminophen, or NSAIDs 48 hrs prior to psychophysical testing * have had more than two previous cesarean sections * have a vertical abdominal incision from a prior cesarean section * are non-English speaking * have mental health issues * have a failure of spinal anesthetic and require conversion to general anesthesia * have a vertical uterine incision performed during ongoing cesarean section * have a previous vertical uterine scar discovered during ongoing cesarean section

Locations (5)

Stanford University

Stanford, California, United States

ACTIVE_NOT_RECRUITING

University of Washington

Seattle, Washington, United States

RECRUITING

St. Luc Hospital, University Catholic of Louvain

Brussels, Brussels Capital, Belgium

Central Contacts

Lisa Y Flint, BS

CONTACT

(206) 543-7817 lyflint@u.washington.edu

Katrina L Golub, MPH

CONTACT

(206) 616-9209 kgerber@u.washington.edu

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.