Total Marrow Irradiation & Autologous Stem Cell Transplantation for Relapsed or Refractory Myeloma

Inclusion Criteria: * A subject must meet all of the following criteria to be eligible for the study. These will be evaluated within the four weeks prior to enrolment. * Subject must have primary refractory or relapsed multiple myeloma. * Subject must have a measurable serum or urine monoclonal gammopathy at the time of their latest relapse. * Subject must meet institutional guidelines for autologous HSCT with adequate renal, cardiac, pulmonary and hepatic function. * An autologous hematopoietic stem cell graft containing more than 2.5 x 106 CD34+ cells/kg must be cryopreserved and available for transplantation. * Subject must be of age more than 18 and less than 60 years. * Subject must have an ECOG performance score of 0,1, or 2. * Subject must have the ability to comply with the protocol visit schedule and other protocol requirements. Exclusion Criteria: * A subject meeting any of the following criteria is not eligible for participation in the study: * Subject with non-secretory multiple myeloma or any plasma cell disorders other that MM. * Subjects that have not received previous therapy with adequate intense corticosteroids for multiple myeloma. * Subjects with a severely limited life expectancy by concomitant illness, defined as a life-expectancy of less than 6 months. * Subjects who have previously received radiation treatments or other neoplastic disorders. * Subjects with a history of non-compliance in other studies. * Pregnant or lactating female subjects.