The primary objective is to study the value of serum procalcitonin as a predictive marker for severe bacterial infection in febrile infants. 2200 febrile infants aged less than 3 months will prospectively be included. All infants will have a measure of Procalcitonin concentrations. Comparison of the mean value of Procalcitonin concentration in infants with and without serious Bacterial infection. Evaluation of the area under the ROC for Procalcitonin concentration.
Serious bacterial infections are often difficult to detect in infant with fever without source. Procalcitonin is a better blood marker of infection than White blood cell count and possibly than C-reactive protein. This could lead to a reduction in antibiotic prescription. Our objective is to evaluate the impact of Procalcitonin result on antibiotic prescription in children 1 to 3 month old with fever without source and our hypothesis is that it will lower the antibiotic prescription rate.
Study Type
OBSERVATIONAL
Enrollment
2,209
Pediatric Emergency Depatment - Hôpital Antoine Béclère
Clamart, Hauts-de-Seine, France
Area under the ROC curve of the serum Procalcitonin concentration in the diagnosis of serious bacterial infections
Time frame: At the day of emergency consultation for fever
Diagnostic value (sensibility and specificity) of clinical examination versus procalcitonin
Time frame: At the day of emergency consultation for fever
Diagnostic value (sensibility and specificity) of complete blood count versus procalcitonin
Time frame: At the day of emergency consultation for fever
Diagnostic value (sensibility and specificity) of CRP versus procalcitonin
Time frame: At the day of emergency consultation for fever
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