A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks.

University of California, Irvine21 enrolled

Overview

The purpose of this study is to improve port wine stain therapeutic outcome in response to laser therapy. The researchers want to determine whether the combined use of pulsed dye laser therapy and rapamycin will improve PWS therapeutic outcome.

The researchers want to combined use of pulsed dye laser to induce port wine stain blood vessel injury, and rapamycin directly inhibits the proliferation of vascular endothelial cells driven by vascular endothelial growth factor which preventing port wine stain angiogenesis and recanalization, to improve port wine stain lesion blanching.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Port Wine Stain

Interventions

Rapamycin Treatment of Port Wine StainDRUG

Treatment of Port Wine Stain

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * port wine stain birthmarks suitable for comparison testing. Exclusion Criteria: * Pregnancy. * Abnormal blood hematology or chemistry blood tests or urine analysis. * History of cancer, History of high cholesterol, lipids or liver disease * Allergy to macrolide drugs (e.g., erythromycin). * Any therapy within the previous two months to the proposed PWS treatment sites. * Concurrent use of known photosensitizing drugs,immunosuppressive drugs or systemic steroids,antifungals, antiepileptics, HIV protease inhibitors, cimetidine, cisapride, clarithromycin, dannzol, diltiazem, erythromycin, metoclopramide, rifabutin, rifampin, rifapentine, troleandomycin, or verapamil.

Locations (1)

Beckman Laser Institute Medical clinic

Irvine, California, United States

Outcomes

Primary Outcomes

improve port wine stain (PWS) therapeutic outcome

Time frame: 8 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.