Increased Expression of Adiponectin Receptor 2 in the Mononuclear Cells in Children With Prader-Willi Syndrome

Samsung Medical Center

Overview

The inflammatory process is involved in the pathogenesis of obesity. Prader-Willi syndrome (PWS) is a genetic model of syndromic obesity. Adiponectin is an adipokine with potent anti-inflammatory properties, and its effect is mediated through adiponectin receptors 1 (adipoR1) and 2 (adipoR2). Objective of this study is to compare the expression of adipoR1, adipoR2, and adiponectin in peripheral blood mononuclear cells (PBMCs) in PWS children and obese control and to correlate receptor expression with insulin sensitivity and obesity-related parameters.

Study Type

OBSERVATIONAL

Conditions

Obesity Prader-Willi Syndrome

Eligibility

Sex: ALLMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * children with Prader-willi syndrome * children with simple obesity Exclusion Criteria: * subjects with diabetes mellitus (fasting plasma glucose \> 126 mg/dL with a 2-h oral glucose tolerance test value of \>200 mg/dl)

Data from ClinicalTrials.gov

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