PET Imaging and Bariatric Surgery

Vanderbilt University Medical Center7 enrolled

Overview

The purpose of this study is to look at certain areas of the brain that are related to addictive behaviors, such as overeating. These areas are called 'dopamine type 2 receptors' (DRD2/3) and other studies have shown that obese people have less of these. We propose that low DRD2/3 availability seen in morbidly obese subjects will change with weight loss associated with bariatric surgery.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Obesity, Morbid

Interventions

F-18 (fallypride)DRUG

Subjects undergoing bariatric surgery will have Positron Emission Tomography (PET)scans of their brains using the radioligand fallypride before and after the operation.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Ages 18-60 years * BMI equal to or greater than 40, or equal to or greater than 35 if there are 2 or more co-morbidities * Weight less than 350 pounds Exclusion Criteria: * History of substance abuse,including but not limited to alcohol, cocaine, marijuana, heroin, nicotine * History of psychiatric disorders * Use of any antidepressants or psychotropics in the past 12 months * Diabetes Mellitis * Positive pregnancy test * Any condition felt by the PI or co-investigators to interfere with the individual's ability to complete the study * Subjects on medications for the last 3 months, such as sibutramine, which could affect the quality of the study, as determined by the PI * Inability to travel to Nashville, TN four times

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Outcomes

Primary Outcomes

Regional DRD2/3 Binding Percent Changes After Bariatric Surgery

Time frame: ~7 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.