Topiramate to Aid Smoking Cessation in Alcohol Dependent Men

Inclusion Criteria: Subjects will be included if they: * are 18-70 years of age, inclusive; * are male outpatients with a diagnosis of DSM-IV-TR nicotine dependence and alcohol dependence in early full remission (1-36 months abstinence); * are current tobacco smokers who smoke an average of 10 or more cigarettes per day in the two months prior to the screening visit; * are motivated to try to quit smoking and maintain abstinence from alcohol and other illicit drugs; Exclusion Criteria: Subjects will be excluded if they: * have any clinically significant laboratory evidence of hematologic, hepatic, cardiovascular, renal, pulmonary, or thyroid disease; * have a current significant neurologic, hepatic, renal, gastrointestinal, pulmonary, metabolic, cardiovascular, infectious, or endocrine disease; * have a history of known hypersensitivity to topiramate; * in the investigator's judgment, pose a current suicidal or homicidal risk; * have taken any investigational drug within 30 days of baseline; and * have a current seizure disorder or a history of severe alcohol withdrawal (alcohol withdrawal seizures, hallucinations / illusions, delirium tremens).