A Clinical Study to Determine Biomarkers of Response to a Gamma Secretase Inhibitor

Inclusion Criteria: * Patient is a male * Patient has no clinically significant abnormality on electrocardiogram performed * Patient agrees to not to consume apple juice, grapefruit or grapefruit products beginning 2 weeks prior to first dose of study drug and for the duration of the study * Patient has been a nonsmoker and/or has not used nicotine or nicotine-containing products for approximately 6 months. * Patient is willing to not use any hair enhancement product or procedures for the duration of the study (for example, permanents, hair straightening techniques) * Patient has a full head of hair * Patient has at least 90% non-gray hair Exclusion Criteria: * Patient has had treatment with any investigational therapy during the prior 21 days * Patient has any history of significant gastrointestinal abnormalities within the last 10 years * Patient has a history of any long-term or active liver disease including elevated liver blood tests. Any patient with a history of Hepatitis B or C (and/or treated previously) will be excluded * Patient has a known history or family history of aortic valve disease, congenital (from birth) heart disease or deafness, hearing loss or early onset Alzheimer's disease (onset at age \< 55) * Patient has a known sensitivity to the ingredients in the drug * Patient has had active and uncontrolled infection within the past month * Patient is HIV positive * Patient has a history of stomach, intestine, heart, blood, liver, brain, kidney, lung, bladder or endocrine abnormalities or diseases * Patient has a history of cancer except for certain skin cancer (basal cell) * Patient has a history of multiple and/or severe allergies or has had an allergic reaction to food or prescription/non-prescription drugs * Patient has had major surgery, donated or lost 1 unit of blood (about 500 mL) within the past month * Patient has premature graying hair (\> 10% gray hair) * Patient has male pattern hair loss * Patient has a prior history of high blood pressure * Patient uses any medication, including prescription and non-prescription drugs or herbal remedies (such as St. John's Wort) beginning approximately 2 weeks prior to the first dose of study drug, throughout the study until the post study visit * Patient consumes excessive amounts of alcohol (greater than 3 glasses of alcoholic beverages) * Patient consumes excessive amounts (greater than 6 servings) of coffee, tea, cola or other caffeinated beverages per day * Patient is a regular use (including "recreational use") of any illicit drugs, has a positive urine drug screen before randomization or has a history of drug (including alcohol) abuse within approximately the past 2 years * Patient has prior exposure to MK 0752 with the past 21 days