Gene Transfer for Cancer Pain

Inclusion Criteria: 1. Patients with intractable pain from malignant disease with a 5 year projected survival of less than 25%. 2. Female patients of childbearing potential who have a negative pregnancy test and using birth control. 3. Patients who have not received recent treatment with a radiation, chemotherapeutic or immunotherapeutic agent and are not expected to undergo such treatment 28 days after injection of NP2. 4. Patients who have not had surgical stabilization/resection within 4 weeks of Screening and have no plans for additional surgical procedures. 5. Patients with adequate bone marrow function, IgG levels greater than 565 mg% and CD4 count greater than 500. . Exclusion Criteria: 1. Patients with serious uncontrolled medical conditions other than malignancy. 2. Patients with severe liver or renal impairment 3. Patients currently or previously with positive serology for HIV, Hepatitis B or Hepatitis C. 4. Patients with a hemoglobin \<9 gm% or uncontrolled coagulopathy or bleeding diathesis. 5. Patients with a clinical diagnosis of any active herpes infection within the past 6 months. 6. Patients who have been vaccinated to prevent HSV infection or a history of shingles or the presence of active shingles.