Transcorneal Electrical Stimulation Therapy for Retinal Disease

Okuvision GmbH80 enrolled

Overview

Transcorneal stimulation may enable neurons to survive degeneration processes via enhanced secretion of neurotrophic substances and direct stimulation of neurons.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Retinitis Pigmentosa Macula Off Primary Open Angle Glaucoma Hereditary Macular Degeneration Treated Retina Detachment Retinal Artery Occlusion

Interventions

Transcorneal Electrical StimulationDEVICE

Neurostimulator drives Dawson-Trick-Litzkow electrode attached to patient eye. Different modi are used to stimulate patients.

DTL-electrode attached without energyDEVICE

DTL-electrode attached to patient eye receives no energy from neurostimulator. Treatment times remain the same as used for each treatment arm.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Retinitis pigmentosa, Macula off, Primary open angle Glaucoma, Hereditary Macular Degeneration, Treated Retina detachment, Retinal Artery Occlusion, Retinal Vein Occlusion, Non-Arthritic-Anterior-Ischemic Optic-Neuropathy, Hereditary autosomal dominant Optic atrophy, dry Age-related Macular Degeneration, Ischemic Macula edema Exclusion Criteria: * Severe other disease such as non-proliferative diabetic retinopathy, exudative Age-related Macular Degeneration * Age above 99 years

Outcomes

Primary Outcomes

enhanced field of vision, enhanced visual acuity, lower threshold for electrical evoked phosphenes

Time frame: 3 years

Data from ClinicalTrials.gov

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