NSAIDS are associated with adverse GI effects and COX-2 inhibitors have cardiovascular risk. Long-term oral supplementation with fish oil reduce e.g. joint pain in rheumatoid arthritis (R.A) patients, with reduced need for NSAIDS, in addition to being cardioprotective. The aim is to investigate if 4 month supplementation of 15 ml/day of whale blubber oil compared with cod liver oil reduce the intensity of joint pain in patients with R.A (primary outcome). Patients are assessed at inclusion and after study (4 months) during routine polyclinical visit. Patients are called for interview after 6 and 12 weeks. Secondary outcomes are e.g. morning stiffness, quality of life and functional level
Not relevant
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
7
15 ml/day for 4 months, divided on dosage morning and evening, orally.
15 ml/day for 4 months, divided on dosage morning and evening, taken orally
To detect a difference in 10 mm on visual analogue scale (intensity of joint pain last week) between the two treatment groups
Time frame: At study end (4 months)
To detect a group difference in morning stiffness last week in minutes (720 min = 12 hours are limit for duration of morning stiffness recorded)
Time frame: Study end (4 months)
To detect a difference between groups in quality of life using SF-36
Time frame: Study end (4 months)
To see a group difference in functional level using MHAQ
Time frame: Study end (4 months)
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