Iron Overload in Stem Cell Transplant Recipients

Boston Children's Hospital38 enrolled

Overview

The goal of this study is to examine the impact of iron overload in patients undergoing a bone marrow transplant. We believe that the iron status in these patients is associated with complications for transplant survivors. We will examine the iron status in these patients by MRI and by screening for mutations in genes known to cause iron overload. We will also determine the levels of hepcidin (a hormone produced in the liver that appears to regulate iron homeostasis) from blood and urine.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Iron Overload

Eligibility

Sex: ALLMin age: 5 Years

Medical Language ↔ Plain English

1. Undergoing allogeneic HSCT for malignant or non-malignant conditions 2. Age greater than or equal to 5 years 3. Able to undergo MRI without a need for general anesthesia 4. No metal implants 5. Signed informed consent (by parent if patient is less than 18 years old, or by patient, if he or she is greater than 18 years old).

Locations (1)

Children's Hospital Boston

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Hepatic iron content as measured by R2 MRI.

Time frame: Pre-HSCT and Day 100

Secondary Outcomes

Genetic determinants of iron overload- HFE status.

Time frame: Pre-HSCT

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.