This 3 arm study will evaluate the efficacy and safety of adding Avastin versus placebo to a standard chemotherapeutic regimen in patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) who have not received prior chemotherapy. The anticipated time of study treatment is until disease progression, and the target sample size is 500+ individuals.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
1,044
80mg/m2 iv on day 1 of each 3 week cycle, for a maximum of 6 cycles
1250mg/m2 on days 1 and 8 of each 3 week cycle for a maximum of 6 cycles
iv on day 1 of each 3 week cycle until disease progression
Progression-free survival
Time frame: Event driven
Efficacy: Duration of overall survival, time to treatment failure, response rate, and duration of response.
Time frame: Event driven
Safety:AEs, laboratory tests, SAEs, coagulation parameters
Time frame: Throughout study
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
15mg/kg 1v on day 1 of each 3 week cycle until disease progression
7.5 mg/kg iv on day 1 of each 3 week cycle until disease progression
Unnamed facility
Bahía Blanca, Argentina
Unnamed facility
Buenos Aires, Argentina
Unnamed facility
Buenos Aires, Argentina
Unnamed facility
Mendoza, Argentina
Unnamed facility
San Miguel de Tucumán, Argentina
Unnamed facility
Santa Fe, Argentina
Unnamed facility
Santa Fe, Argentina
Unnamed facility
Adelaide, Australia
Unnamed facility
Adelaide, Australia
Unnamed facility
Brisbane, Australia
...and 144 more locations