A Comparison of Three Medications to Treat Diarrhea in Adults.

Inclusion Criteria: * Male or female at least 18 years of age * Acute diarrhea illness with symptoms onset within 48 hours of study entry * Minimum of 3 unformed stools in 24 hours before study entry * Most recent stool is unformed * Abdominal discomfort/wind (intensity mild to severe) within 4 hours of study entry * Women of childbearing potential must have a negative pregnancy test at screening * Willing to adhere to the prohibitions and restrictions specified in this protocol * Subjects must have signed an informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study Exclusion Criteria: * Requiring hospital admission, parenteral hydration or antibiotic therapy Axillary temperature \>38.2°C or oral temperature \>38.6°C * History or clinical evidence of gross blood or pus in stool in current illness * Signs or symptoms of orthostatic hypotension * Unable to take medication and fluids by mouth * History of chronic gastrointestinal disease, hepatic or renal insufficiency, or other significant medical condition that could be aggravated by untreated acute diarrhea * Immunodeficiency (e.g. those with acquired immunodeficiency syndrome \[AIDS\] or known human immunodeficiency virus \[HIV\] infection, or undergoing chemotherapy or radiotherapy) * Intake of antibiotics, oral antifungals, quinidine or ritonavir within 7 days, antidiarrhoeal, promotility drugs (e.g., metoclopramide, domperidone), antiflatulents (e.g., simeticone, activated charcoal) or probiotics or bismuth salts within 48 hours, or any analgesic within 6 hours prior to study entry Hypersensitivity to loperamide, yeast, or any component of study formulations * Pregnant or breast-feeding * Unable to comply with the protocol requirements and schedule * Any condition that, in the opinion of the investigator, would compromise the well-being of the subject or the study * Use of opiates (as 'recreational' drugs and as painkillers)