The aim of this study is to determine whether contingent reinforcement for smoking abstinence, compared to noncontingent reinforcement, increases the effectiveness of brief counseling and nicotine replacement on smoking abstinence of substance abusers in residential treatment.
Substance abusers have a high prevalence and rate of smoking with little success in quitting, so stronger approaches are needed to encourage attempts to quit smoking. The aim of this study is to determine whether contingent reinforcement for smoking abstinence (CM), compared to noncontingent reinforcement (NR), increases the effectiveness of brief counseling and nicotine replacement on smoking abstinence of substance abusers in residential treatment. The proposed study will be a 2-group design in which up to 274 substance abusers who smoke 10 or more cigarettes per day receive brief advice (4 sessions) and nicotine replacement (NRT) (8 weeks), and are randomized to 19 days of CM for smoking vs. a matched NR condition. The brief advice is adapted slightly for sobriety settings. Point-prevalence abstinence will be assessed at 1, 3, 6 and 12 months after starting treatment. Secondary aims evaluate effects of CM on substance use outcomes and potential mediators of effects on outcome, including within-treatment abstinence, motivation level and tolerance for smoking discomfort. The significance is to add knowledge about the most effective ways to maximize smoking cessation among substance abusers, important given that no methods are known to work with this population.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
340
Nicoderm CQ nicotine skin patch: 21mg patch for 4 weeks, 14mg patch for 2 weeks, 7mg patch for 2 weeks. This is supplemental intervention provided to all.
Brief Advice (BA): Patients will receive four sessions of a manualized brief intervention based on NCI guidelines (Manley et al., 1991; Hollis et al., 1993) as modified for sobriety settings. This simple counseling has five components: (1) Assess smoking and initial interest in cessation; (2) Advise the patient to quit smoking; (3) Assist the patient in quitting; (4) Assess interest in quitting; and (5) Arrange booster sessions. This supplemental information is provided to all.
Brown University, Center for Alcohol and Addiction Studies
Providence, Rhode Island, United States
Number of Participants Smoking Abstinent in Past 7 Days
7 -day smoking cessation confirmed by expired alveolar CO levels of \< 10 ppm or salivary cotinine \< 16 ng/ml.
Time frame: 1-month follow-up
Number of Participants Smoking Abstinent in Past 7 Days
7 -day smoking cessation confirmed by expired alveolar CO levels of \< 10 ppm or salivary cotinine \< 16 ng/ml.
Time frame: 3-month follow up
Number of Participants Smoking Abstinent in Past 7 Days
7 -day smoking cessation confirmed by expired alveolar CO levels of \< 10 ppm or salivary cotinine \< 16 ng/ml.
Time frame: 6-month follow up
Number of Participants Smoking Abstinent in Past 7 Days
7 -day smoking cessation confirmed by expired alveolar CO levels of \< 10 ppm or salivary cotinine \< 16 ng/ml.
Time frame: 12-month follow up
Average Number of Cigarettes Per Day
Time frame: 1-month follow up
Average Number of Cigarettes Per Day
Time frame: 3-month follow up
Average Number of Cigarettes Per Day
Timeline Followback interview assessing number of cigarettes on each day of each 3-month reporting period
Time frame: 6-month follow up
Average Number of Cigarettes Per Day
Time frame: 12-month follow up
Number of Participants With Relapse to Any Heavy Drinking
Heavy drinking = 6 or more drinks for men; 5 or more drinks for women
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Condition provides contingent monetary reinforcement for smoking reductions (first 5 days) then for smoking abstinence (subsequent 14 days). Expired carbon monoxide (CO) levels will be the basis for determining reductions and abstinence.
Controls for effects of receiving payments, providing daily breath samples for CO level, and degree of interaction between patient and research staff. NR will allow them to earn an amount which is matched in amount to the expected average earned in CM contingent only on providing breath samples independent of the CO level attained.
Time frame: 1-month follow up
Number of Participants With Relapse to Any Heavy Drinking
Heavy drinking = 6 or more drinks for men; 5 or more drinks for women
Time frame: 3-month follow up
Number of Participants With Relapse to Any Heavy Drinking
Heavy drinking = 6 or more drinks for men; 5 or more drinks for women
Time frame: 6-month follow up
Number of Participants With Relapse to Any Heavy Drinking
Heavy drinking = 6 or more drinks for men; 5 or more drinks for women
Time frame: 12-month follow up
Number of Participants With Relapse to Any Drug Use
Time frame: 1-month follow up
Number of Participants With Relapse to Any Drug Use
Time frame: 3-month follow up
Number of Participants With Relapse to Any Drug Use
Time frame: 6-month follow up
Number of Participants With Relapse to Any Drug Use
Time frame: 12-month follow up
Percent Smoking Days
Time frame: 1-month follow up
Percent Smoking Days
Time frame: 3-month follow up
Percent Smoking Days
Time frame: 6-month follow up
Percent Smoking Days
Time frame: 12-month follow up