Study of Techniques of Subcutaneous Administration of Fluids Enabled by Human Recombinant Hyaluronidase

Inclusion Criteria: * male or female, aged 18 to 60 years * intact normal skin without potentially obscuring features on both anterior thighs in the area intended for infusion * agreeing to no fluid intake for 12 hours prior to start of study infusion * vital signs within normal range or, if outside normal range, deemed not clinically significant * metabolic panel, hematology, virology and standard 10-test urine dipstick tests within normal range, or if outside normal range, deemed not clinically significant * if female of child-bearing potential,negative serum pregnancy tests * negative urine drug screens * written informed consent for participation Exclusion Criteria: * lower extremity edema * lower extremity pathology that could interfere with study outcome * history of cardiovascular disease * rales on lung auscultation * known allergy to hyaluronidase or other ingredient in the formulation of hylenex * pregnancy or breast-feeding a child * exposure to any experimental drug within 30 days prior to study participation * previous participation in this study