The purpose of this study is to examine if the ingestion of a standard dose of sildenafil enhances the athletic performance of competitive athletes when exercising in a high pollutant environment verses a low air pollutant environment.
This study will evaluate effects of sildenafil on exercise performance while breathing high levels of emission exhaust ultrafine and fine particulate matter. Exercise performance will be measured by work accumulation (total kJ) during a 6-min maximal effort cycle ergometer ride (CER) done immediately after 30 min cycling at 75% of 6 min mean watts determined from familiarization trial. Peak oxygen consumption, cardiac output, pulmonary artery pressure, diffusion capacity(DLco), and SaO2 will be determined for each trial. Blood and urine will be analyzed for sildenafil using LC/MS.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
24
sildenafil 50 mg ingested orally 1 hour prior to exercise testing
matching placebo for sildenafil 50 mg to be ingested orally 1 hour prior to exercise testing.
Marywood University
Scranton, Pennsylvania, United States
That a decrease in exercise performance subsequent to emissions particle inhalation will be blunted by oral ingestion of 50 mg sildenafil prior to a 6-min maximal accumulation test (total kJ)on a cycle ergometer.
Time frame: Cycle ergometer testing will be done one hour after administration of sildenafil or matching placebo.
That the decreased VO2 peak and decreased exercise performance from emissions inhalation will be the result of pulmonary hypertension causing decreased stroke volume.
Time frame: Pulmonary artery pressure will be measured before and immediately post exercise.
That plasma and urine sildenafil and metabolites will be measurable by liquid chromatography mass spectrometry (LC/MS) 6 h post ingestion.
Time frame: Blood and urine samples will be collected at 1, 3, 1nd 6 hours post exercise testing.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.