Study of NU172 as Anticoagulation in Patients Undergoing Off-pump CABG Surgery

Inclusion Criteria: * Must give written informed consent prior to initiation of any study related procedures * Male or female subjects at least 18 years of age * Subject is accepted for primary, elective off-pump CABG surgery with planned sternotomy without other planned concomitant cardiac surgical procedures * New York Heart Association (NYHA) Class III or less heart failure * Available for follow-up assessments Exclusion Criteria: * Prior surgery with median sternotomy * Prior CABG surgery * Women of childbearing potential who are not using adequate contraceptive precautions (e.g. intrauterine device, oral contraceptives,barrier methods, or other contraception deemed adequate by the investigator); women who are pregnant or lactating * Stroke within the previous 6 months * History of stroke with residual neurological deficit * Intracranial neoplasm, arteriovenous malformation or aneurysm * Any prior exposure to NU172 * Contraindication to unfractionated heparin * Refusal to undergo blood transfusion, should it be necessary * Symptomatic gout * Serum uric acid \>11mg/dL at screening * Known bleeding diathesis * Known thrombotic diathesis * Participation in any study of an investigational device, drug or biologic within 30 days prior to planned surgery * Any other disease or condition that, in the judgment of the investigator would interfere with the subject's ability to comply with study procedures and requirements