Regulation of Hepatic Insulin Extraction

Washington University School of Medicine

Overview

* This study is in the area of Type 2 diabetes and genetics * Healthy Volunteers and those with mild type 2 diabetes may be eligible to participate * This study is searching for genes that may affect the body's processing/digestion of glucose/sugar

This study is looking at the genetic influences of type 2 diabetes. It also is investigating the various gastric hormones including but not limited to: insulin, C-peptide, GIP, GLP, \& Xenin.

Study Type

OBSERVATIONAL

Conditions

Diabetes

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ages 18-65 * non-diabetic * diabetes controlled with diet or with pills * no family history of diabetes * family history of type 2 diabetes * personal history of gestational diabetes Exclusion Criteria: * \< 18 or \> 65 years of age * medications that affect glucose (sugar) levels * kidney disease * liver disease * heart/cardiovascular disease

Outcomes

Primary Outcomes

Genes affecting the development of Type 2 diabetes will be identified

Time frame: 1 year

Secondary Outcomes

Any differences between genetic groups in the metabolism of glucose/sugar will be studied to the extent that the data allow

Time frame: 1 year

Data from ClinicalTrials.gov

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