A First Time in Human Study in Healthy Volunteers to Investigate a New Medicine to Treat Malaria

Inclusion Criteria: * Male or female between 18 and 50 years of age, inclusive * Females of non-childbearing potential (as pre-menopausal females with a documented tubal ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous amenorrhea * Body weight \> 50 kg and BMI within the range 19 - 31 kg/m2 (inclusive) * QTcB or QTcF \< 450 msec; or QTc \< 480 msec in subjects with Bundle Branch Block Exclusion Criteria: * Positive pre-study drug/alcohol screen * Positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening. * A positive test for HIV antibody * History of regular alcohol consumption within 6 months of the study * Participation in a clinical trial with an investigational product within 30 days or 5 half-lives of the investigational product (whichever is longer) prior to start of the new study * Exposure to more than four new drugs or within 12 months prior to the first dosing day * Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days or 5 half-lives (whichever is longer) prior to the first dose of study medication * History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that would be contraindicated * Donation of blood or blood products in excess of 500 mL within a 56 day period. * Pregnant females as determined by positive serum or urine hCG test at screening or prior to dosing. * Lactating females. * Unwillingness or inability to follow the procedures outlined in the protocol. * History of sensitivity to heparin or history of heparin-induced thrombocytopenia if heparin is used to maintain the patency of an intravenous cannula. * Asthma or a history of asthma * Smoking or history or regular use of tobacco- or nicotine-containing products within 2 months prior to screening * Consumption of red wine, seville oranges, grapefruit or grapefruit juice and/or pummelos, exotic citrus fruits, grapefruit hybrids or fruit juices from 7 days prior to the first dose of study medication.