A Study to Assess the Safety, Tolerability and Efficacy of RG2417 in Bipolar I Depression

Inclusion Criteria: * Bipolar I Disorder, most recent episode depressed * History of 2 or more manic or mixed episodes, at least one of which required pharmacologic treatment for manic symptoms Exclusion Criteria: * Current manic, hypomanic or mixed episode * Rapid cycling bipolar disorder (4 or more mood episodes in the last year) * Dementia or any other Axis I diagnosis (besides bipolar I) that requires treatment * Alcohol or drug dependence within 6 months; alcohol or drug abuse within 3 months * Positive urine drug test for amphetamines, cocaine metabolites, opiates and/or phencyclidine(PCP) * Axis II diagnosis likely to interfere with study compliance * Serious suicidal or homicidal risk * Sensitivity to any of the drug ingredients, including lactose * Women who are pregnant, breast feeding or refuse to use adequate birth control * Current seizure disorder * Current episode of depression is longer than 1 year