Calcineurin Free Immunosuppression in Renal Transplant Recipients

Inclusion Criteria: * Male or female patients between 15 and 75 years of age, regardless of race. * Female patients of child bearing age agree to maintain effective birth control practice during the study. * Patient has end stage kidney disease and is a suitable candidate for primary renal transplantation or retransplantation as assessed by the transplantation center. * Patient has been fully informed and has given written or independent person witnessed oral informed consent. Exclusion Criteria: * Patient is pregnant or breastfeeding. * Patient has a low immunological risk constellation, defined by receiving a kidney from a HLA-identical related living donor. * Patient has a high immunological risk constellation, defined as having within the previous three years a measured PRA grade of ≥25% and/or having a previous graft survival shorter than 3 years due to rejection. * Patient and donor have a positive T or B-cell crossmatch. * Patient and donor are ABO incompatible. * Age of donor \> 68 years. * Cold ischemia time \> 36 hours. * Patient has leucopenia, defined as having at transplantation less than 3000/mm3 leukocytes. * Patient has thrombocytopenia, defined as having at transplantation less than 75000/mm3 thrombocytes. * Patient is allergic or intolerant to cremophor RH 60 or structurally related compounds, steroids, Cyclosporine A Neoral, Rapamycin or MMF. * Patient requires initial sequential or parallel therapy with immunosuppressive antibody preparation(s). * Patient or donor is known to be HIV positive. * Patient has significant liver disease, defined as having during the past 28 days continuously ASAT (SGOT) and/or ALAT (SGPT) levels greater than 3 fold of the upper value of the normal range of the investigational site. * Patient with malignancy or history of malignancy ≥ 2 years, except non metastatic basal or squamous cell carcinoma of the skin that has been treated successfully. * Patient has significant, uncontrolled concomitant infections and/or severe diarrhea, vomiting, or active peptic ulcer. * Patient is taking or has been taking an investigational drug in the past 28 days. * Patient has previously received or is receiving another organ transplant other than kidney. * Patient is unlikely to comply with the visits schedule in the protocol.