14473 - D9126C00001 Proof of Principle Study - Effect of AZD2066 on Transient Lower Esophageal Sphincter Relaxations

Inclusion Criteria: * Provision of written consent prior to any study specific procedures. * Healthy subjects, age 18-45 years inclusive. Females must be of no childbearing potential or must use a highly effective contraceptive method. * Clinically normal physical findings and laboratory values at the time of pre-entry visit, as judged by the investigator. Exclusion Criteria: * Clinically significant illness within the 2 weeks prior to the first dose of the investigational product, including a suspected/manifested infection according to WHO risk categories 2, 3 or 4, as judged by the investigator. * A measured LES pressure of \< 5mm Hg. * History of previous or ongoing psychiatric disease/condition.