The Effects of Exercise Training on the Health-related Fitness of Colon Cancer Survivors

AHS Cancer Control Alberta52 enrolled

Overview

Recent studies have suggested that individuals diagnosed with colon cancer who are inactive and/or overweight, may have poorer survival outcomes. Exercise training has been shown to improve fitness and body composition in other cancer survivor groups. The investigators hypothesize that an exercise training program will be a safe, feasible, and effective intervention to improve the fitness and body composition of a group of colon cancer survivors.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Colonic Neoplasms

Interventions

Exercise TrainingBEHAVIORAL

The exercise group will perform supervised stationary cycle ergometer exercise 3 times per week for 12 weeks and be progressed from 15 to 45 minutes and 60% to 110% of the power output obtained at V02peak. Resistance training will be completed twice per week and will include exercises for all major muscle groups. The training will progress from 60% to 80% of 1RM over the course of the intervention.

Usual CareOTHER

Usual Care

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Histologically confirmed Stage II or III colon cancer diagnosis * Less than or equal to 1 year since the completion of all adjuvant treatment * Negative Physical Activity Readiness Questionnaire (PAR-Q) or completed Physical Activity Readiness Medical Examination (PARmed-X) form * 18 years of age or older * Ability to understand and provide written informed consent in English * Willingness to be randomized * Willingness to complete outcome measures at each assessment time point * Available for the duration of study intervention period * Able to travel to our fitness centre 3/week for the study period Exclusion Criteria: * Any absolute contraindication to to exercise testing or training * Evidence of active disease (metastatic, recurrent, or unresectable colon cancer) * Any uncontrolled medical condition or psychiatric illness that would prevent completion of the exercise program or interfere with the study assessments

Locations (1)

Cross Cancer Institue

Edmonton, Alberta, Canada

Outcomes

Primary Outcomes

Safety (Monitoring for Adverse Events)

Time frame: 12 Weeks

Secondary Outcomes

Change in Aerobic Capacity

Time frame: Baseline and 12 Weeks

Change in body composition

Time frame: Baseline and 12 Weeks

Feasibility (Adherence to the exercise training program)

Time frame: 12 weeks

Data from ClinicalTrials.gov

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