Effect of β-alanine Supplementation on Muscle Carnosine

Société des Produits Nestlé (SPN)30 enrolled

Overview

Carnosine is a natural acid buffering substance of muscle. The primary objective of this study is to test whether a nutritional supplement of beta-alanine enhances carnosine content in muscle.

Volunteers will be randomized to receiving 3 nutritional supplements. Two supplements contain beta-alanine at different doses, the third supplement is a placebo.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

QUADRUPLE

Enrollment

Conditions

Healthy

Interventions

placeboDIETARY_SUPPLEMENT

daily

beta-alanineDIETARY_SUPPLEMENT

daily

beta-alanineDIETARY_SUPPLEMENT

daily

Eligibility

Sex: MALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Stable health as evaluated by medical evaluation * Body mass index higher than 18 kg/m2 * Body mass index lower than 25 kg/m2, unless body fat is less than 20% Exclusion Criteria: * intolerance to β-alanine, * allergy to soy, fish and crustacean * participation in another intervention study * consumer of dietary supplement susceptible to contain beta-alanine * determined to have very high baseline muscle carnosine concentration

Locations (1)

University and Inselspital

Bern, Canton of Bern, Switzerland

Outcomes

Primary Outcomes

muscle carnosine concentration

Time frame: 0 to 8 weeks

Data from ClinicalTrials.gov

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