Gemcitabine or Gemcitabine and Cisplatin in the Treatment of Advanced Pancreatic Cancer

Inclusion Criteria: * Histologic or cytologic diagnosis pancreatic cancer * inoperable stage II or stage III or IV disease(UICC, 1997) * Age 18 to 75 years * Karnofsky Performance status \> 50 * Signed informed consent Exclusion Criteria: * Previous chemotherapy * Cerebral metastases * Previous malignancies in past 5 years excluding adequately treated basal or spinocellular skin cancers and insitu cervical cancer * Leukocytes \< 4000 or neutrophils \< 2000 or platelets \< 100000 or hemoglobin \< 10 g/dl * Creatinine value \> upper normal limit * GOT or GPT \> 2.5 times upper normal limit or bilirubin \> 1.5 times upper normal limit in absence of hepatic metastases * Congestive heart failure, severe cardiac arrhythmias or coronary ischemic disease * Other concurrent disease that would, in the investigator's opinion, contraindicate the use of the study drugs * Inability to provide informed consent * Inability to comply with follow-up.