Double-Masked Trial of NOVA22007 (Ciclosporin 0.1%) Versus Vehicle in Patients With Moderate to Severe Dry Eye Syndrome

Inclusion Criteria: * Males or females 18 years of age or greater. * At baseline, moderate to severe dry eye condition persisting despite conventional management. Exclusion Criteria: * Presence or history of any systemic or ocular disorder or condition, including ocular surgery, trauma or disease that could possibly interfere with the interpretation of study results. * Any relevant ocular anomaly interfering with the ocular surface, including post radiation keratitis, Stevens-Johnson syndrome, corneal ulcer history or concomitant corneal ulcer of infectious origin, etc. * Any other ocular diseases requiring topical ocular treatment during the study period. * Patient who has participated in a clinical trial with a new active substance during the past month before study entry. * Participation in another clinical study at the same time as the present study.