Safety of the HIV Vaccine 732462 in HIV Infected Subjects Aged 18 to 55 Years Old

Inclusion Criteria: All subjects must satisfy the following criteria at screening and before vaccination: * A male or female, aged between and including 18-55 years at the time of first vaccination. * Known to be HIV-1 infected and under care of an HIV physician for a minimum of 6 months. However, subjects who initially presented with primary HIV infection need to have been diagnosed and under care for 12 months. * Written informed consent obtained from the subject prior to any study procedure. * Subjects who the investigator believes that they can and will comply with the requirements of the protocol. * If the subject is female, she must be of non-childbearing potential, or if she is of childbearing potential, she must practice adequate contraception for 30 days prior to vaccination, have a negative pregnancy test and continue such precautions throughout the duration of the study. * CD4 count ≥ 450 cells per mm³ Additional inclusion criteria for subjects enrolled in the first cohort (HIV-infected subjects receiving HAART): * Stable on highly active antiretroviral therapy (HAART) for at least one year. * Undetectable viral load Additional inclusion criteria for subjects enrolled in second cohort (treatment-naïve HIV-infected subjects): * HAART-naïve (never received anti-retrovirals after HIV diagnosis) * VL 5000-80000 copies/mL at screening * Commencement of HAART is not expected based on current assessment within next year. Exclusion Criteria: The following criteria should be checked at the time of screening and before vaccination. If any apply, the subject must not be included in the study: * Infection with HIV-2 * Had an AIDS defining illness (CDC Classification). * Use of any investigational or non-registered product (drug or vaccine) within 30 days preceding the first dose of study vaccine/placebo, or planned use of any investigational or non-registered product other than the study vaccine during the study period. * Drug therapy with immunomodulators or steroids within the three months preceding the first dose of study vaccine/placebo or planned administration during the study period * Administration of immunoglobulins and/ or any blood products within the three months preceding the first dose of study vaccine/placebo or planned administration during the study period. * Planned administration of a vaccine not foreseen by the study protocol during the period starting 30 days before the first dose of study vaccine/placebo and ending at Month 4 It is recommended that the vaccination history of all subjects has been reviewed with their health care provider and that they have been encouraged to be fully vaccinated according to their country vaccination schedule for HIV- infected persons before enrolment into this study. * Concurrently participating in another clinical study, at any time during the study period, in which the subject has been or will be exposed to an investigational or a non-investigational product (pharmaceutical product or device). * Any previous vaccination or immunotherapy against HIV. * History of immune reconstitution disease when commencing antiretroviral therapy (for HIV-infected subjects receiving HAART) * A family history of hereditary immunodeficiency. * History of allergic disease or reactions likely to be exacerbated by any component of the vaccine. * Acute or chronic infective hepatitis (A past history of hepatitis B or C is not an exclusion criterion). * Acute or chronic, clinically relevant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory screening tests. * Pregnant or lactating female. * Female planning to become pregnant or planning to discontinue contraceptive precautions. * Any condition (including alcohol and drug abuse) which, in the opinion of the investigator, could compromise the subject's safety or adherence to the study protocol * History of medically confirmed autoimmune disease * History of malignancy, other than squamous cell or basal cell skin cancer, unless there has been surgical excision that is considered to have achieved cure * Asthma requiring daily steroid or long acting ß agonist prevention * Unstable asthma defined as: * Sudden acute attacks occurring in less than three hours without an obvious trigger. * Hospitalisation for asthma in the last two years * Food or wine induced asthma * Known sensitivity to sulfites or aspirin * Known sensitivity to aminoglycoside antibiotics