An Open Label Positron Emission Tomography (PET) Study of GSK618334 in Healthy Male Subjects Using 11C-PHNO as PET Ligand

Inclusion Criteria: * healthy, male subjects aged between 30 and 55 old inclusive. * normal body weight. * normal ECG and vital signs. * agree to use acceptable contraceptive methods required. * capable of giving written informed consent. Exclusion Criteria: * smoker or uses other nicotine-containing products. * certain medical conditions including heart disease, neurological disease, gastrointestinal disease, kidney or liver dysfunction - abnormal laboratory tests. * certain psychiatric conditions and use of certain psychoactive drugs . * positive blood alcohol or urine drug test. * alcohol intake over 14 drinks per week. * participation in another drug trial within 30 days or a study involving significant radiation exposure. * donation of more than 450 mL blood within the 56 days. * family history of cancer (one or more first-degree relative diagnosed before the age of 55 years old). * having cardiac pacemaker or other electronic device. * suffers from claustrophobia or feels that he will be unable to lie still on his back in the PET camera.