Remifentanil and Atropine for Intubation in Neonates

King Saud University30 enrolled

Overview

The investigators hypothesize that the use of a combination of Atropine and Remifentanil will safely facilitate non emergent intubation procedure as effectively as the protocol of Atropine, Fentanyl, and Succinylcholine.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Endotracheal Intubation

Interventions

Atropine/RemifentanilDRUG

Atropine 20mcg/kg Remifentanil 3mcg/kg

Fentanyl/Atropine/SuccinylcholineDRUG

Atropine 20mcg/kg Fentanyl 2mcg/kg Succinylcholine 2mg/kg

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Hemodynamically stable neonates of any gestational age admitted to the Neonatal Intensive Care Unit at McMaster Children's Hospital requiring an elective endotracheal intubation was anticipated. Exclusion Criteria: * Urgent intubations * Cyanotic congenital heart lesions * Anticipated difficult airway * Concurrent or recently administered (within 3 hours of the procedure) intravenous opioid infusions * Pre-existing hyperkalemia * Family history of malignant hyperthermia * Prior enrollment

Locations (1)

McMaster University NICU

Hamilton, Ontario, Canada

Outcomes

Primary Outcomes

Time to Successful intubation

Time frame: 15 minutes

Secondary Outcomes

Time to return of spontaneous respirations

Time frame: 15 minutes

Oxygen saturation

Time frame: During the procedure up to 15 minutes

Heart Rate

Time frame: During the procedure up to 15 minutes

Blood Pressure

Time frame: During the procedure up to 15 minutes

Intubation Condition

Time frame: 15 minutes post procedure

Evidence of Trauma

Time frame: 15 minutes post procedure

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.