Effects of the Ivabradine on Reduction of Inflammatory Markers in Patients With Acute Coronary Syndrome

Inclusion Criteria: 1. Male or female. 2. Age \> 18 years. 3. Ischemic symptoms suspected to represent a non-ST segment elevation acute coronary syndrome defined as: Clinical history consistent with new onset, or a worsening pattern, of characteristic ischemic chest pain occuring at rest or with minimal exertion (lasting longer than 10 min) and planned to be managed with an early invasive strategy with intention to perform a percutaneous coronary intervention as early as possible and not later than 72 hours of randomization, and at least one of the following: 1. ECG changes compatible with new ischemia (ST depression of at least 1 mm or transient ST elevation or ST elevation of \<1 mm or T wave inversion \>3 mm in at least 2 contiguous leads; or 2. Already elevated cardiac enzymes (eg, CK-MB) or biomarkers (troponin I or T) above the upper limit of normal. 4. Patients should be in sinus rhythm with a resting HR of \> 60 beats per minute on a resting standard 12-lead ECG. 5. Written informed consent obtained. Exclusion Criteria: 1. Patients unlikely to cooperate in the study or with inability or unwillingness to give informed consent. 2. Pregnant or breast-feeding women or women of childbearing potential. 3. Patients with recent (\< 6 months) myocardial infarction or coronary revascularization or with a history of stroke or cerebral transient ischemic attack within the preceding 3 months or scheduled for revascularization (percutaneous coronary intervention and coronary artery bypass graft). 4. Patients with at least 1 of the following criteria: * Implanted pacemaker or implantable cardioverter defibrillator. * Valvular disease likely to require surgery within the next 2 years. * Sick sinus syndrome, sinoatrial block, congenital long QT syndrome, complete atrioventricular block. * Expectation of death from other illness during the course of the trial. * Known severe liver or renal disease. * Requiring or likely to require the following medications: macrolide antibiotics, cyclosporin, gestodene, antiretroviral drugs or azole antifungals such as ketoconazole or with known hereditary problems of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. 5. Patients with systemic or cardiac inflammatory processes with the exception of atherosclerosis.