This was a 1-week study of desloratadine (DL) plus oxybutynin (OXY) at two dose levels in the treatment of post-nasal drip in participants with seasonal allergic rhinitis. Participants received either desloratadine twice a day, oxybutynin twice a day, desloratadine plus lower-dose oxybutynin twice a day, desloratadine plus higher-dose oxybutynin twice a day, or placebo for 7 days.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
540
Desloratadine 2.5 mg BID
Oxybutynin 2.5 mg BID
Placebo BID
Change from baseline in mean daily AM/PM Prior post-nasal drip scores averaged over the entire treatment period
Time frame: Days 1 to 7 +/- 2 days
Anterior rhinorrhea averaged over Days 1 to 8
Time frame: Days 1 to 8
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Placebo BID