Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat

University of Aarhus8 enrolled

Overview

Hypothesis: under fasting there will primarily be an activation of growth hormone(GH) signalpathways and a inhibition of insulin signalpathways, and the opposite will happen under physical activity. Primarily we will investigate markers for GH and insulin signaltransduction in muscle- and fat-biopsies after fasting for 72 hours and after 1 hour of ergometer-cycling at 65% Vo2max. In addition to this we will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

ExerciseOTHER

1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.

FastingOTHER

3 days of fasting and then the same as arm 1

Eligibility

Sex: MALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy men * Body mass index (BMI) 20-26 * age 18-45 years Exclusion Criteria: * any kind of disease * any use of medicine

Locations (1)

Aarhus sygehus

Aarhus, Jylland, Denmark

Outcomes

Primary Outcomes

Growth hormone and insulin signal pathways

Time frame: 30 min

Secondary Outcomes

aminoacid and glucose turnover

Time frame: 4 hours

Data from ClinicalTrials.gov

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