Sleep Disturbances as a Non-traditional Risk Factor in CKD-Actigraphy

University of Chicago353 enrolled

Overview

To test if usual at home night time sleep duration as measured with activity monitors and questionnaires will predict changes in kidney function as measured by kidney filtration rate and of cardiovascular function as measured by C-reactive protein in the blood. The study will explore the role of decreased sleep time or decreased sleep quality as a non-traditional risk factor for the progression of CKD and for the development of cardiovascular disease in CKD.

Study Type

OBSERVATIONAL

Enrollment

353

Conditions

Chronic Kidney Disease Sleep Loss

Eligibility

Sex: ALLMin age: 21 YearsMax age: 74 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Mild to Moderate CKD * Healthy controls age and gender matched to CKD subjects * Regular bedtimes of at least 6h/night, sedentary lifestyle Exclusion Criteria: * Diabetes * Current or previous dialysis for more than 1 month * Uncontrolled hypertension * Heart failure * Liver disease * HIV * Hemoglobin \< 10.5 g/dl * Treatment with EProcrit, Epogen, or Aranesp * Bone or organ transplant, * Use of immunosuppressive drugs within past 6 months * Current oral contraceptive use * Current pregnancy * Chemotherapy for malignancy within past 2 years

Locations (1)

The University of Chicago

Chicago, Illinois, United States

Outcomes

Primary Outcomes

CKD progression as measured by changes in GFR and cardiovascular risk as measured by CRP over a 5 year period

Time frame: 5 years

Secondary Outcomes

insulin resistance

Time frame: 5 years

Data from ClinicalTrials.gov

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