Long Term Administration Study of OPC-12759 Ophthalmic Suspension

Inclusion Criteria: 1. Out patient; 2. Ocular discomfort severity is moderate to severe; 3. Corneal-conjunctival damage is moderate to severe; 4. Unanesthetized Schirmer's test score of 5mm/5minutes or less,or tear breakup time is 5 seconds or less; 5. Best corrected visual acuity of 0.2 or better in both eyes. Exclusion Criteria: 1. Presence of anterior segment disease or disorder other than that associated with keratoconjunctivitis scicca; 2. Ocular hypertention patient or glaucoma patient with ophthalmic solution; 3. Anticipated use of any topically-instilled ocular medications or patients who cannot discontinue the use during the study; 4. Anticipated use of contact lens during the study; 5. Patient with punctal plug; 6. Any history of ocular surgery within 12 months; 7. Female patients who are pregnant, possibly pregnant or breast feeding; 8. Known hypersensitivity to any component of the study drug or procedual medications; 9. Receipt of any investigational product within 4 months.