Effect of Vecam 40/300 and Vecam 20/300 Compared to Omeprazole 20 mg on Gastric pH

Inclusion Criteria: * Healthy, H. pylori negative status (by Urea Breath Test) * Male or female subjects * Age 18-55 years * Able to tolerate the placement of a nasogastric pH probe at screening * Baseline Gastric pH≤2 * Use of acceptable form of birth control in females with child-bearing potential * Had not used any form of tobacco (e.g. smoking or chewing) for the last year * Can swallow a size "00" capsule without difficulty * Willing to comply with study protocol * Signed Informed Consent form Exclusion Criteria: * BMI \> 40 * Slow or poor Omeprazole metabolizers (heterozygous or homozygous, respectively) based on CYP2C19 genotyping test. * Any significant history of / or concurrent gastrointestinal diseases or conditions such as: * GERD * Acute gastrointestinal bleeding * Zollinger Ellison Syndrome or Gastric hypersecretory condition * Known Barrett's esophagus * Esophageal stricture * Peptic ulcer disease (gastric or duodenal) or family history of peptic ulcer disease * Gastric outlet obstruction * Gastroparesis * Significant medical history or concurrent illness as determined by the principal investigator * Any medical disorder that alters the normal gastric acid secretion profile as determined by the principal investigator * History of diabetes mellitus * Significant laboratory abnormalities as determined by the principal investigator * Known metabolic alkalosis, hypocalcemia, sodium restricted diet, hypokalemia, respiratory alkalosis * Pregnant or lactating women * Had been treated with any investigational drug or therapy or participated in a clinical trial within 30 days prior to entering the trial * Use of any medication other than contraception or hormone replacement therapy; OTC drugs other than vitamins or occasional acetaminophen within 30 days prior to entering the trial or during the trial * Use of NSAID medications within 30 days prior to entering the trial (e.g. Ibuprofen, Aspirin, Naproxen etc) * Positive urine test for alcohol or other drugs * Concurrent use of gastric anti-secretory drugs such as defined below: * Use of a PPI 30 days prior to each stage or during the trial * Use of H2RA 14 days prior to each stage or during the trial * Concurrent use of antacids (including over-the-counter) 24 hours prior to each stage or during the trial * Use of any medication that modifies gastric acid secretion 30 days prior to or during the trial. * Had ingested grapefruit within 14 days of dose administration in any trial period * Significant drug allergy or known hypersensitivity to any of the ingredients in the trial drugs Omeprazole, Succinic Acid or to Lidocaine * Consumption of coffee within 48 hours of dose administration in any trial period. * Had donated blood within 30 days of entering the trial * Known positive serology for HBV, HCV or HIV * Any reason which makes the subject a poor candidate based on the physician's discretion