Nuclear Factor Kappa-B (NFKB1) Polymorphism and Organ Injury After Cardiac Surgery

N/ACompletedNCT00819871

Changhai Hospital105 enrolled

Overview

NFKB1 -94ins/del polymorphism has been reported to be associated with reduced promoter activity of NFKB1 and several clinical diseases, but the clinical results cannot always be replicated. Besides, mutate allele is associated with alleviated inflammation in ulcerative colitis and some tumors, but aggravated inflammation in ARDS. The clinical value of this polymorphism remains controversial. This study was performed to investigate the association of NFKB1 -94ins/delATTG polymorphism with lung and/or kidney injury after cardiac surgery with CPB.

Study Type

OBSERVATIONAL

Enrollment

105

Conditions

Single Nucleotide Polymorphism Acute Lung Injury Kidney Injury

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Chinese Han unrelated population * undergoing elective cardiac surgery with CPB Exclusion Criteria: * malignant tumor * autoimmune disease, immunodeficiency or immunosuppressive therapy * chronic renal disease (glomerular filtration rate \< 60ml/(min•1.73m2)) or liver dysfunction (Child Pugh classification\>A) * COPD, tuberculosis or other chronic pulmonary diseases * anemia with hemoglobin lower than 90mmHg * bleeding disorders * postoperative pericardial tamponade requiring re-operation * postoperative low cardiac output syndrome or acute pulmonary edema after left cardiac failure.

Outcomes

Primary Outcomes

lung injury and/or kidney injury after cardiac surgery with cardiopulmonary bypass

Time frame: 24h after cardiac surgery

Secondary Outcomes

circulating level of CRP, TNF-alpha, IL-10; APACHE Ⅱ score; duration of ICU stay and hospitalization; death in 28 days

Time frame: one month after cardiac surgery