Ocular Biodistribution Study for Topically Applied ESBA105

Inclusion Criteria: * Male or female Caucasian patients ≥18 years. * Written informed consent prior to any study procedures including screening tests for eligibility. * Patients should be in good health as determined by past medical history, physical examination, vital signs, electrocardiogram (ECG), and laboratory tests at screening. * Ability to administer eye drops (personally or administered by another person). Cataract patients: * Eligible for routine, uncomplicated senile cataract surgery. Vitrectomy patients: * Diagnosis of epiretinal fibroplasia requiring vitrectomy and cataract surgery. Exclusion Criteria: * Treated glaucoma / elevated intraocular pressure (IOP) requiring therapy. * History of chronic or recurrent intraocular inflammatory disease. * Uncontrolled diabetes mellitus (fasting blood glucose \>15 mmol/L). * Diabetic retinopathy with history of laser photocoagulation. * Patients with a single eye or a pinholed visual acuity (VA) 20/200 or worse measured on Snellen chart in the non-study eye. * Iris atrophy in the eye to undergo surgery. * Pregnant or breast-feeding women or women of childbearing potential, who with their partners refuse to use 2 reliable methods of contraception * History of collagenosis or systemic vasculitis. * Patients who have had ocular surgery (including laser surgery) in the study eye within 3 months or in the contralateral eye within 2 weeks prior to screening. * Patients who have an active systemic or local (anywhere in the body) bacterial and/or viral infection. * Positive or unclear QuantiFERON-TB Gold assay result. * Participation in a clinical study with investigational drugs within 3 months prior to screening. * Inability to comply with the study requirements. * Patients with known, severely impaired hepatic function, or laboratory values reflecting inadequate hepatic function. * Patients with pre-existing chronic renal failure defined by a calculated creatinine clearance (CrCl) of \< 40 mL/min, using the Cockcroft-Gault estimate for glomerular filtration rate