Feasibility of Permacol Use in Infected Fields

Inclusion Criteria: * Have given written Informed Consent * Be 18-85 years of age (inclusive) * Have prosthetic mesh that is in proximity to an infected wound that has failed conservative management for at least 3 months, with mesh exposure and a draining wound, or that is in proximity to an abscess that requires operative intervention. * Have a wound characterized by purulent discharge, positive gram stain or positive culture to document infection * Be a candidate for surgical removal of infected mesh placed for repair of ventral/incisional hernias and concomitant abdominal wall reconstruction * Have an ASA Score ≤3 * Have a body mass index (BMI) between 16.5 and 40 inclusive * Be a candidate for anticipated primary approximation of skin/wound * Have a life expectancy of at least 18 months * Be willing to allow biopsy of implant if secondary wound opening is performed or spontaneous implant exposure occurs Exclusion Criteria: * Have loss of abdominal domain such that the operation would be impractical or would adversely effect respiratory or cardiovascular function to an unacceptable degree * Have an enterocutaneous fistula in proximity to wound/mesh * Be a candidate for emergency surgery that would make giving valid Informed Consent impractical * Be currently taking part in another clinical study that conflicts with the current study * Have known allergy to porcine collagen products * Have active generalized peritonitis or intraperitoneal sepsis * Have active necrotizing fasciitis * Have active abdominal compartment syndrome * Have active untreated metabolic or systemic illness * Report unintentional weight loss \>10% of body weight in the previous 90 days * Have known collagen metabolism disorder.(e.g., Ehlers-Danlos syndrome) * Have known altered immune response (e.g., HIV or other immunodeficiency disorder)) * Have chronic renal failure * Have known active malignancy present * Have history of systemic chemotherapy within previous 1 year * Have lifetime history of radiation to the abdomen, pelvis or thorax * Have inguinal or groin hernia as primary diagnosis * Be currently pregnant or planning to become pregnant during study period * Be unable to give valid informed consent or comply with required follow- up schedule * Suffer from mental capacity sufficiently severe to make informed consent unobtainable