The DIEP Flap as a Model of Ischemia-Reperfusion: an Intervention Study

Maastricht University Medical Center30 enrolled

Overview

The investigators will examine whether administration of certain medications will decrease or prevent ischemia-reperfusion injury.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Ischemia-Reperfusion

Interventions

AntioxidantDRUG

Antioxidant iv bolus

PlaceboOTHER

Placebo tablet and iv

Anti-inflammatory drugDRUG

Anti-inflammatory tablet

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing breast reconstruction Exclusion Criteria: * Diabetes mellitus * Kidney or liver disease * Use of immunosuppressants

Locations (1)

Maastricht University Medical Center

Maastricht, Netherlands

Outcomes

Primary Outcomes

Antioxidant concentrations

Time frame: 0,5-24 hours

Central Contacts

Marieke van den Heuvel, M.D.

CONTACT

0031-43-3875496 m.vandenheuvel@ah.unimaas.nl

R. van der Hulst, M.D., Phd

CONTACT

0031-43-3877481 r.vander.hulst@mumc.nl

Data from ClinicalTrials.gov

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