The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery

Robert Kramer, MD120 enrolled

Overview

Acute kidney injury is associated with cardiopulmonary bypass during heart surgery and its pathogenesis is similar to that of ischemia-reperfusion injury. Remote ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in patients undergoing coronary bypass surgery. The investigators hypothesize that such preconditioning reduces the incidence of acute kidney injury associated with cardiopulmonary bypass.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

120

Conditions

Acute Kidney Insufficiency Acute Renal Insufficiency Acute Kidney Injury Ischemic Preconditioning

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient undergoing heart surgery on cardiopulmonary bypass. Exclusion Criteria: * Known peripheral vascular disease of the lower extremities associated with active skin necrosis or infection. * End-stage renal disease. * Inability to give informed consent.

Outcomes

Primary Outcomes

Incidence of acute kidney injury, after surgery, as defined by elevation in serum creatinine greater than or equal to 0.3 mg/dl.

Time frame: 48 hours after surgery.

Secondary Outcomes

Oliguria.

Time frame: 12 hours after surgery.

Incidence of acute kidney injury as defined by post-operative elevation in NGAL.

Time frame: 3 hours after cardiopulmonary bypass.