Blood Glucose Homeostasis in Type 2 Diabetes: the Effects of Saccharose

Maastricht University Medical Center39 enrolled

Overview

Hyperglycemia forms a direct and independent risk factor for the development of cardiovascular co-morbidities in type 2 diabetes. Consumption of sucrose-sweetened soft drinks might further increase the prevalence of hyperglycemic episodes. The objective of the study was to assess glycemic control in type 2 diabetes patients and healthy lean and obese controls under strict dietary standardization but otherwise free living conditions, with and without the consumption of soft drinks.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Type 2 Diabetes Glycemic Control

Interventions

Sucrose consumptionDIETARY_SUPPLEMENT

Sucrose

water consumptionDIETARY_SUPPLEMENT

water

Eligibility

Sex: MALEMin age: 40 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Lean NGT Group * Normoglycemic (according to 2006 ADA guidelines) * BMI \< 27 kg/m2 Obese NGT Group * Normoglycemic * BMI 30- 35 kg/m2 Obese type 2 diabetes Group * BMI 30- 35 kg/m2 * Oral blood glucose lowering medication Exclusion Criteria: * Exogenous insulin use * Cardiac disease (any cardiac event in the last 5 years) * HbA1c \>10% * Microalbuminuria: albumin:creatinine ratio \>2,5

Locations (1)

Maastricht University

Maastricht, Limbrug, Netherlands

Outcomes

Primary Outcomes

Hyperglycemia

Time frame: 24h

Secondary Outcomes

Hyperglycemia

Time frame: Postprandially

Data from ClinicalTrials.gov

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